Female Mice Delay Reproductive Aging in Males1

Mammalian oogenesis and female reproductive aging

Longitudinal, epidemiologic studies of female reproductive aging.

Human female reproductive aging consists of multiple processes and interacts with other physiological systems in unique ways. Here we discuss eight recent longitudinal, epidemiologic studies of female reproductive aging that include endocrine data to highlight their contributions to our understanding of these various aging processes and their interactions. Specifically, we review data on ovaria...

effects of portulaca oleracea ethanolic extract on reproductive system of aging female mice

background: aging contains morphological and functional deterioration in biological systems. d-galactose (d-gal) generates free radicals and accelerates aging. portulaca oleracea (purslane) may have protective effect against oxidative stress. objective: purslane ethanolic extract effects were evaluated on antioxidant indices and sex hormone in d-gal aging female mice. materials and methods: 48 ...

The acceleration of reproductive aging in Nrg1 flox/flox ;Cyp19‐Cre female mice

Irregular menstrual cycles, reduced responses to exogenous hormonal treatments, and altered endocrine profiles (high FSH/high LH/low AMH) are observed in women with increasing age before menopause. In this study, because the granulosa cell-specific Nrg1 knockout mice (gcNrg1KO) presented ovarian and endocrine phenotypes similar to older women, we sought to understand the mechanisms of ovarian a...

Effects of Portulaca oleracea ethanolic extract on reproductive system of aging female mice

BACKGROUND Aging contains morphological and functional deterioration in biological systems. D-galactose (D-gal) generates free radicals and accelerates aging. Portulaca oleracea (Purslane) may have protective effect against oxidative stress. OBJECTIVE Purslane ethanolic extract effects were evaluated on antioxidant indices and sex hormone in D-gal aging female mice. MATERIALS AND METHODS 48...